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Highest Quality | For Research Use Only

Buy LL-37 Peptide Ireland

LL-37, also known as cathelicidin antimicrobial peptide, is a critical component of the innate immune response. This 37-amino acid peptide has been extensively studied for its broad-spectrum antimicrobial activity and its modulatory effects on the host immune system.

LL-37 exerts its antimicrobial action primarily through disruption of microbial membranes, leading to cell death. However, it’s not solely an antimicrobial agent; Ireland research suggests it also plays a pivotal role in immunomodulation. It can bind to specific receptors, such as the formyl peptide receptor-like 1 (FPRL1) and the purinergic receptor P2X7, triggering a cascade of cellular responses that include chemotaxis, wound healing, and angiogenesis.

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Potential Benefits of LL-37 Peptide

  • LL-37 peptide exhibits potent antimicrobial and anti-biofilm properties, making it a potential candidate for treating bacterial infections and biofilm-related diseases [1] and [2].
  • The peptide has been explored as a potential treatment for polymicrobial infected wounds due to its antimicrobial action [3].
  • LL-37 peptide is naturally secreted by human mesenchymal stem cells, contributing to their antimicrobial effect. This finding suggests the peptide’s role in innate immunity and its potential use in stem cell therapies [4] and [5].
  • Research has shown that LL-37 peptide can be successfully loaded onto nanoparticles for targeted drug delivery, indicating its potential in nanomedicine and treatment of drug-resistant bacterial infections [6].
  • According to research, the antibacterial activity of LL-37 peptide can be inhibited by salivary mucins, highlighting the importance of understanding the peptide’s interactions with other biological molecules for therapeutic applications [7].
  • In the context of cystic fibrosis, LL-37’s antimicrobial activity can be inhibited when complexed with glycosaminoglycans in the lungs. However, studies indicate this inhibition can be reversed by hypertonic saline, suggesting a potential therapeutic strategy [8].
  • Research suggests LL-37 peptide has immunomodulatory and tissue repair properties, further expanding its therapeutic potential [9].
  • There is ongoing research into the role of LL-37 peptide in COVID-19 inflammatory responses and microthrombosis, indicating its relevance in current global health issues [10].

References

[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC8227053/

[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5374219/

[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3699762/

[4] https://www.sciencedirect.com/science/ article/pii/S2405844019363121

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3293245/

[6] https://www.sciencedirect.com/science/ article/abs/pii/S1385894722005903

[7] https://pubmed.ncbi.nlm.nih.gov/18456648/

[8] https://pubmed.ncbi.nlm.nih.gov/19542465/

[9] https://pubmed.ncbi.nlm.nih.gov/25101632/

[10] https://pubmed.ncbi.nlm.nih.gov/35634307/

DISCLAIMER: We do not supply peptides to any individual under the age of 21. You must be a licensed and qualified healthcare practitioner. Our team of dedicated professionals are committed to providing an extensive range of products used ONLY in the process of laboratory research by responsible trained and professional individuals. All products listed on this website (https://ireland.direct-peptides.com) and provided through Direct Peptides are intended for laboratory research purposes only. The products listed on this website are NOT for human or animal consumption or ingestion of any kind.