Buy AICAR Peptide Ireland

AICAR peptide is a key research tool for understanding metabolic processes, particularly its influence on skeletal muscle and lipid metabolism. By activating specific signaling pathways, AICAR modulates cell activities, potentially impacting the regulation of adipose tissue and body weight management.

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AICAR Nasal Spray
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AICAR 50mg Pre Mixed
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AICAR
£27.08 – £36.06
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What Is AICAR?

AICAR is a chemical that helps cells manage energy. It is also called 5-Aminoimidazole-4-carboxamide ribonucleotide. The peptide works as a substitute for adenosine monophosphate (AMP). It acts like a signal within the cell, mimicking exercise effects. When AICAR is present, it turns on a key enzyme called AMPK (AMP-activated protein kinase). This enzyme helps control how the cell uses energy, particularly from sugar and fat.

By using AICAR, cells can increase their uptake of sugar and break down fatty acids more efficiently. This process is beneficial for conditions like obesity and type 2 diabetes. It helps improve the body’s energy use without actual physical exercise. Ireland Researchers are interested in how it could help treat metabolic issues.

AICAR Mechanism Of Action

AICAR works by affecting the energy processes within cells. Notably in skeletal muscle and adipose tissue. When introduced into the body, it enters cells and influences a key enzyme known as AMPK (AMP-activated protein kinase). This enzyme is integral to the lipid metabolism and energy balance within the body.

Upon activation by AICAR, AMPK enhances glucose uptake in muscle cells and increases the oxidation of fatty acids. This improved lipid metabolism allows the body to utilize stored fats more efficiently for energy. Through these actions, it mimics the effects of physical exercise at the cellular level. This promotes better management of energy resources and signalling pathways.

Consequently, this can lead to positive changes in body weight. It also offers therapeutic benefits for metabolic conditions such as obesity and diabetes. This makes AICAR a promising agent for improving overall metabolic health and influencing the activity of adipocytes (fat cells).

Structure of AICAR

Sequence: 5-amino-4-imidazolecarboxamide ribotide

Molecular Formula:
C9H15N4O8P

Molecular Weight:
338.21 g/mol

PubChem CID: 66510

What Are The Research Benefits of AICAR

AMPK Activation: AICAR, or 5-Aminoimidazole-4-carboxamide ribonucleotide, is known to boost the activity of AMP-activated protein kinase (AMPK). AMPK plays a crucial role in maintaining cellular energy balance, which makes AICAR useful for regulating metabolism [1].

Enhanced Endurance: Ireland Studies have shown that the peptide can enhance endurance in mice by transforming fast-twitch muscle fibers into the more energy-efficient, fat-burning, slow-twitch type [2]. This can improve the body’s ability to withstand prolonged physical activity.

Cardioprotection: The peptide has demonstrated cardioprotective properties. It has been found to limit infarct size during ischemia and improve post-ischemic heart function [3].

Neuroprotection: Ireland Research suggests that it has potential neuroprotective effects. It may mitigate neuronal damage after incidents such as stroke or spinal cord injury [4].

Potential Treatment for Obesity: Obesity is a condition where individuals have excess body fat that negatively impacts their health. It has been studied for its potential in managing obesity by enhancing fatty acid oxidation and promoting energy balance [5].

Management of Type 2 Diabetes: Type 2 diabetes is a metabolic disorder caused by insulin resistance, leading to high blood sugar levels. Ireland Research suggests that it could potentially improve insulin sensitivity, making it a potential treatment option for type 2 diabetes [6].

Promotes Mitophagy and Autophagy: Ireland Studies have shown that the peptide can induce mitophagy (removal of damaged mitochondria) [7] and autophagy (recycling of old or damaged cellular components) [8], which are important processes for maintaining healthy cells [9].

Cancer Therapy Potential: While more research is needed, Ireland studies suggest it might have potential in cancer therapy due its ability to inhibit cell proliferation and induce apoptosis in certain cancer cell lines [10].

Inflammation Modulation: It has been observed to exert anti-inflammatory effects, which may have significant implications in the treatment of chronic inflammatory diseases [11].

Anti-Aging Effects: The peptide has been studied for its potential anti-aging effects, as it has shown to increase the lifespan of different organisms in laboratory studies. Further research is needed to fully understand the mechanisms behind this potential benefit.

Buy AICAR Peptide Vial Ireland for in research online today! Available in 50mg online here at Direct Peptides.

Buy AICAR Pre-Mixed Pen

The AICAR pre-mixed pen offers a convenient and user-friendly solution for research use. This pre-loaded device eliminates the need for mixing, ensuring ease of use and precise dosing. The pen is designed to deliver consistent amounts of the peptide, making it ideal for studies requiring accurate administration.

The simple design lets researchers focus on their experiments without the worry of preparation errors.This device supports effective metabolic research and energy regulation. Therefore aiding in the advancement of scientific knowledge. The pre-mixed pen is a practical choice for those seeking efficient and reliable peptide delivery.

Buy AICAR Ireland 50 mg Pre Mixed Pen here. Available to buy as a pre-mixed cartridge or as a kit which includes a pen for the cartridge, needle tips, and a case to hold everything.

Buy AICAR Nasal Spray

Buy AICAR nasal spray, it is designed to deliver a peptide that helps control metabolism and energy levels. This new method allows the compound to be absorbed quickly through the nasal mucosa. Studies have shown it enters the bloodstream faster than injections.

The spray comes in 15 ml and 30 ml bottles, offering a simple option without the need for needles. This makes it easier for researchers to manage doses when studying AICAR’s effects on endurance, insulin response, and inflammation. As Ireland studies expand, using a nasal spray offers a practical and easy way to explore this peptide.

Buy AICAR nasal spray Ireland here from Direct Peptides.

Frequently Asked Questions (FAQs) about AICAR Peptide

What are the primary uses of AICAR?

It is widely researched for its potential benefits in enhancing endurance, cardioprotection, and neuroprotection. It is also a possible treatment for conditions like obesity and type 2 diabetes. It is also being studied for its anti-aging effects and potential in cancer therapy.

How is AICAR administered?

It can be administered through various methods, including injections, nasal sprays, and pre-mixed pens. The nasal spray method offers quick absorption and is a needle-free alternative to traditional injections.

What are the potential side effects of AICAR?

Research is ongoing, and while it shows promise, potential side effects can include fatigue, changes in blood pressure, and alterations in glucose metabolism. It is important for researchers to monitor these effects closely in studies.

Is AICAR legal and safe for use?

It is not approved by the FDA (United States Food and Drug Administration) for human use, and its safety in humans has not been fully established. It is currently used in research settings only. While studies show potential benefits, it is vital to consider that research is still ongoing. Comprehensive clinical trials are necessary to ascertain its safety and efficacy fully.

It’s crucial to remain cautious while using AICAR in experimental studies. Ireland Researchers must adhere to legal guidelines and investigate potential risks thoroughly. Understanding the regulatory landscape surrounding the peptide can help ensure responsible research practices.

Can AICAR be used in sports?

It is prohibited in competitive sports by the World Anti-Doping Agency (WADA). This is due to its potential performance-enhancing effects. Athletes should ensure compliance with anti-doping regulations when considering substances like AICAR.

Buy AICAR peptide supplies for all your reconstitution requirements from Direct Peptides Ireland.

Summary of Research Applications

Enhances glucose uptake in muscle cells, aiding in better energy utilization.
Stimulates fatty acid oxidation, helping the body to use fats more efficiently.
Mimics effects of exercise on a cellular level, offering potential benefits without physical activity.
May improve insulin sensitivity, which is important for managing type 2 diabetes.
Supports effective energy management, which could aid in treating obesity.
Potential to serve as a therapeutic option for metabolic disorders.
Under research for wider applications in metabolic health improvement.

AICAR Peptide Quality Assured

At Direct Peptides, when you choose to buy AICAR, we ensure that it is top quality. We focus on delivering products that meet the highest standards. Each batch undergoes rigorous testing to ensure it is at least 98% pure, providing researchers with reliable and effective materials for their studies.

This commitment to quality guarantees that researchers receive a product they can depend on for their work. By choosing Direct Peptides, you’re selecting a trusted source for your research needs. Our dedication to providing reliable peptides makes us a preferred partner in scientific research and innovation.

References For Further Reading

[1] D Grahame Hardie (2007) AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy – Nature Reviews: Molecular Cell Biology, 2007 Oct, Volume 8 (Issue 10), Pages 774-85.

[2] Vihang A. Narkar, Michael Downes, Ruth T. Yu, Emi Embler, Yong-Xu Wang, et al (2008) AMPK and PPARdelta agonists are exercise mimetics – Cell, 2008 Aug 8, Volume 134 (Issue 3), Pages 405-15.

[3] Tinggui Yin, Gulzar Sandhu, Curt D. Wolfgang, Althea Burrier, et al (1997) Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney* – Volume 272, Issue 32, 8 August 1997, Pages 19943-19950.

[4] Wei Wu, Zhaoyang Ye, Yan Zhou, Wen-Song Tan (2011) AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells – The International Journal of Artificial Organs, 2011 Dec, Volume 34 (Issue 12), Pages 1128-36.

[5] Emma Börgeson, Ville Wallenius, Gulam H Syed, Manjula Darshi , Juan Lantero Rodriguez, et al (2017) AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin – Diabetologia, 2017 Apr, Volume 60 (Issue 4), Pages 729-739.

[6] Miguel A Iglesias, Ji-Ming Ye, Georgia Frangioudakis, Asish K Saha, Eva Tomas, et al (2002) AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats – Diabetes, 2002 Oct, Volume 51 (Issue 10), Pages 2886-94.

[7] Eszter Dombi, Heather Mortiboys, and Joanna Poulton (2018) Modulating Mitophagy in Mitochondrial Disease – Current Medicinal Chemistry, 2018, Volume 25 (Issue 40), Pages 5597-5612.

[8] Rosa Viana, Carmen Aguado, Inmaculada Esteban, Daniel Moreno, et al (2008) Role of AMP-activated protein kinase in autophagy and proteasome function – Biochemical and Biophysical Research Communications, 2008 May 9, Volume 369 (Issue 3), Pages 964-8.

[9] Yachun Han, Shan Xiong, Hao Zhao, Shikun Yang, Ming Yang. et al (2021) Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy – Cell Death Dis, 2021 Oct 30, Volume 12 (Issue 11), Page 1031.

[10] Monica Buzzai, Russell G Jones, Ravi K Amaravadi, Julian J Lum, Ralph J DeBerardinis, et al (2007) Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth – Cancer Research, 2007 Jul 15, Volume 67 (Issue 14), Pages 6745-52.

[11] Duygu Sag, David Carling, Robert D Stout and Jill Suttles (2008) Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype – Journal of Immunology, 2008 Dec 15, Volume 181 (Issue 12), Pages 8633-41.

Why Choose Direct Peptides Ireland?

Buy AICAR Ireland, high purity research peptides from Direct Peptides. We guarantee 99% purity for accurate experiments. Available in vials, nasal sprays, and pre-mixed pens. We focus on quality control to provide reliable results, making us a trusted source for researchers in metabolic studies.

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Ireland Direct Peptides website: https://ireland.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

Buy AICAR Peptide Ireland

Shop our Full Range of AICAR Peptides

AICAR Nasal Spray

AICAR 50mg Pre Mixed

AICAR

What Is AICAR?